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Colorectal cancers and cases of gliomas, urothelial and prostate cancers showed distinct nuclear membrane staining. Remaining cancers were in general weakly stained or negative.
Cancer cells generally showed distinct nuclear membrane immunoreactivity. Several cases of renal and hepatocellular carcinomas displayed weak positivity.
Few cases of lung, liver and breast cancers displayed moderate to strong cytoplasmic staining with additional nuclear positivity in carcinoids. Remaining cancer tissues were weakly stained or negative.
Several cases of liver cancers as well as cases of melanomas, endometrial, ovarian, renal and lung cancers showed moderate cytoplasmic staining. A subset of tumor cells in renal cancers displayed moderate nuclear membranous staining. Remaining cancers were weakly stained or negative.
Most cancer tissues showed moderate to strong nuclear membrane positivity. Few cases of renal cell carcinomas and hepatocellular carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
RANBP2 (HGNC Symbol)
Synonyms
ADANE, ANE1, NUP358
Description
RAN binding protein 2 (HGNC Symbol)
Entrez gene summary
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)