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This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001816 [cytokine production] GO:0004872 [receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0043274 [phospholipase binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0070062 [extracellular exosome] GO:0072593 [reactive oxygen species metabolic process] GO:0090238 [positive regulation of arachidonic acid secretion] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:1900138 [negative regulation of phospholipase A2 activity] GO:1900139 [negative regulation of arachidonic acid secretion]
