Tissue expression of CD96 - Summary - The Human Protein Atlas

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CD96

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CD96
Gene description	CD96 molecule
Protein class	CD markers Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node)
GTEx:	Tissue enhanced (spleen, small intestine)
FANTOM5:	Tissue enhanced (tonsil, appendix)

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA066754
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (tonsil, appendix)

GENE INFORMATION
Gene name	CD96 (HGNC Symbol)
Synonyms	TACTILE
Description	CD96 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband
Chromosome location (bp)	111292719 - 111665750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153283 (version 83.38)
Entrez gene	10225
UniProt	P40200 (UniProt - Evidence at protein level)
neXtProt	NX_P40200
Antibodypedia	CD96 antibodies

PROTEIN BROWSER

CD96-001	CD96-002	CD96-003	CD96-006	CD96-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD96-001 ENSP00000283285 ENST00000283285	P40200 [Direct mapping] T-cell surface protein tactile Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0050776 [regulation of immune response] Show all	585 aa 65.6 kDa	No	1
CD96-002 ENSP00000342040 ENST00000352690	P40200 [Direct mapping] T-cell surface protein tactile Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0050776 [regulation of immune response] Show all	569 aa 63.9 kDa	No	1
CD96-003 ENSP00000389801 ENST00000438817	Q8WUE2 [Direct mapping] CD96 antigen, isoform CRA_b; CD96 protein; T-cell surface protein tactile Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	402 aa 45.6 kDa	No	0
CD96-006 ENSP00000417150 ENST00000465428	H7C4F0 [Direct mapping] T-cell surface protein tactile Show all	Predicted intracellular proteins Show all		146 aa 16.1 kDa	No	0
CD96-007 ENSP00000475194 ENST00000460744	U3KPT0 [Direct mapping] T-cell surface protein tactile Show all	Predicted intracellular proteins Show all		18 aa 2.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.