Cell atlas - ADPRHL1 - The Human Protein Atlas

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ADPRHL1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ADPRHL1
Gene description	ADP-ribosylhydrolase like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (T-47d, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA066478
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066478	MCF7	Nucleoplasm
	HPA066478	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ADPRHL1 (HGNC Symbol)
Synonyms	ARH2
Description	ADP-ribosylhydrolase like 1 (HGNC Symbol)
Entrez gene summary	ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]
Chromosome	13
Cytoband	q34
Chromosome location (bp)	113399610 - 113453524
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153531 (version 83.38)
Entrez gene	113622
UniProt	Q8NDY3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NDY3
Antibodypedia	ADPRHL1 antibodies

PROTEIN BROWSER

ADPRHL1-001	ADPRHL1-002	ADPRHL1-003	ADPRHL1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADPRHL1-001 ENSP00000348894 ENST00000356501	Q8NDY3 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase-like protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003875 [ADP-ribosylarginine hydrolase activity] GO:0051725 [protein de-ADP-ribosylation] Show all	272 aa 31 kDa	No	0
ADPRHL1-002 ENSP00000364567 ENST00000375418	Q8NDY3 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase-like protein 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003875 [ADP-ribosylarginine hydrolase activity] GO:0051725 [protein de-ADP-ribosylation] Show all	354 aa 40.1 kDa	No	0
ADPRHL1-003 ENSP00000416213 ENST00000413169	X6RL45 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase-like protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 20.5 kDa	No	0
ADPRHL1-004 ENSP00000489048 ENST00000612156		MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1967 aa 211.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.