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FBXL2

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GENERAL INFORMATION

Gene name

 FBXL2

Gene description

 F-box and leucine-rich repeat protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane. In addition localized to the nucleus & nucleoli.

RNA cell category

 Cell line enhanced (CAPAN-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

Additional location

 In addition localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA061783
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane. In addition localized to the nucleus & nucleoli.

Main location

 Plasma membrane (supported)

Additional location

 Nucleus (approved), Nucleoli (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA061783 A-431 Nucleus
Nucleoli
Plasma membrane
HPA061783 HeLa Nucleus
Nucleoli
HPA061783 U-2 OS Nucleus
Nucleoli

GENE INFORMATION

Gene name

 FBXL2 (HGNC Symbol)

Synonyms

 FBL2, FBL3

Description

 F-box and leucine-rich repeat protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Chromosome

 3

Cytoband

 p22.3

Chromosome location (bp)

 33277025 - 33403662

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153558 (version 83.38)

Entrez gene

 25827

UniProt

 Q9UKC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKC9

Antibodypedia

 FBXL2 antibodies

PROTEIN BROWSER
FBXL2-001
FBXL2-006
FBXL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXL2-001
ENSP00000417601
ENST00000484457
Q9UKC9 [Direct mapping]
F-box/LRR-repeat protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0010506 [regulation of autophagy]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0019903 [protein phosphatase binding]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 423 aa
47.1 kDa 		No 0
FBXL2-006
ENSP00000426163
ENST00000507198
Q9UKC9 [Direct mapping]
F-box/LRR-repeat protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0006508 [proteolysis]
GO:0010506 [regulation of autophagy]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0019903 [protein phosphatase binding]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 355 aa
39.6 kDa 		No 0
FBXL2-201
ENSP00000441228
ENST00000538892
Q9UKC9 [Direct mapping]
F-box/LRR-repeat protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0006508 [proteolysis]
GO:0010506 [regulation of autophagy]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0019903 [protein phosphatase binding]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 355 aa
39.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.