Expression of PTPRD in cancer - Summary

CANCER ATLAS

Gene description

Protein tyrosine phosphatase, receptor type, D

Protein class

Enzymes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA054829

GENE INFORMATION
Gene name	PTPRD (HGNC Symbol)
Synonyms	HPTP, PTPD
Description	Protein tyrosine phosphatase, receptor type, D (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Chromosome	9
Cytoband
Chromosome location (bp)	8314246 - 10612723
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153707 (version 83.38)
Entrez gene	5789
UniProt	P23468 (UniProt - Evidence at protein level)
neXtProt	NX_P23468
Antibodypedia	PTPRD antibodies

PROTEIN BROWSER

PTPRD-001	PTPRD-002	PTPRD-003	PTPRD-006	PTPRD-008	PTPRD-201	PTPRD-202	PTPRD-203	PTPRD-204	PTPRD-205	PTPRD-206

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRD-001 ENSP00000417661 ENST00000463477	C9J8S8 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	202 aa 22.4 kDa	Yes	0
PTPRD-002 ENSP00000370593 ENST00000381196	P23468 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030182 [neuron differentiation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0097105 [presynaptic membrane assembly] Show all	1912 aa 214.8 kDa	Yes	1
PTPRD-003 ENSP00000417093 ENST00000486161	P23468 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030182 [neuron differentiation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0097105 [presynaptic membrane assembly] Show all	1505 aa 169.6 kDa	Yes	1
PTPRD-006 ENSP00000380731 ENST00000397606	P23468 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030182 [neuron differentiation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0097105 [presynaptic membrane assembly] Show all	1505 aa 169.5 kDa	Yes	1
PTPRD-008 ENSP00000417890 ENST00000481079	C9J6E4 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	93 aa 10.4 kDa	Yes	0
PTPRD-201 ENSP00000347373 ENST00000355233	P23468 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030182 [neuron differentiation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0097105 [presynaptic membrane assembly] Show all	1506 aa 169.7 kDa	Yes	1
PTPRD-202 ENSP00000348812 ENST00000356435	P23468 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030182 [neuron differentiation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0097105 [presynaptic membrane assembly] Show all	1912 aa 214.8 kDa	Yes	1
PTPRD-203 ENSP00000380735 ENST00000397611	P23468 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030182 [neuron differentiation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0097105 [presynaptic membrane assembly] Show all	1502 aa 169.3 kDa	Yes	1
PTPRD-204 ENSP00000380741 ENST00000397617	F5GWR7 [Direct mapping] Protein-tyrosine-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	1505 aa 169.4 kDa	Yes	1
PTPRD-205 ENSP00000440515 ENST00000537002	Q3KPI9 [Direct mapping] PTPRD protein; Receptor-type tyrosine-protein phosphatase delta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	1496 aa 168.7 kDa	Yes	1
PTPRD-206 ENSP00000438164 ENST00000540109	P23468 [Direct mapping] Receptor-type tyrosine-protein phosphatase delta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030182 [neuron differentiation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0097105 [presynaptic membrane assembly] Show all	1912 aa 214.8 kDa	Yes	1