Cell atlas - MCOLN2 - The Human Protein Atlas

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MCOLN2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	MCOLN2
Gene description	Mucolipin 2
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the intermediate filaments.
RNA cell category	Cell line enhanced (HDLM-2, THP-1, Daudi, U-698)
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA019114 , HPA048999
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, THP-1, Daudi, U-698) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the intermediate filaments.

Main location

Intermediate filaments (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019114	A-431	Cytosol
	HPA019114	U-2 OS	Intermediate filaments
	HPA019114	U-251 MG	Intermediate filaments
	HPA048999	HEK 293	Nucleoplasm
	HPA048999	HEK 293	Intermediate filaments
	HPA048999	U-2 OS	Intermediate filaments
	HPA048999	U-251 MG	Intermediate filaments

GENE INFORMATION
Gene name	MCOLN2 (HGNC Symbol)
Synonyms	FLJ36691, TRP-ML2, TRPML2
Description	Mucolipin 2 (HGNC Symbol)
Entrez gene summary	Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]
Chromosome	1
Cytoband	p22.3
Chromosome location (bp)	84925583 - 84997113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153898 (version 83.38)
Entrez gene	255231
UniProt	Q8IZK6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IZK6
Antibodypedia	MCOLN2 antibodies

PROTEIN BROWSER

MCOLN2-001	MCOLN2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCOLN2-001 ENSP00000359640 ENST00000370608	Q8IZK6 [Direct mapping] Mucolipin-2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	566 aa 65.9 kDa	No	5
MCOLN2-005 ENSP00000284027 ENST00000284027	Q8IZK6 [Direct mapping] Mucolipin-2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	538 aa 62.7 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.