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DGKE

GENERAL INFORMATION

Gene name

 DGKE

Gene description

 Diacylglycerol kinase, epsilon 64kDa

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA017167
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DGKE (HGNC Symbol)

Synonyms

 DAGK6, DGK

Description

 Diacylglycerol kinase, epsilon 64kDa (HGNC Symbol)

Entrez gene summary

 Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 56834099 - 56869567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153933 (version 83.38)

Entrez gene

 8526

UniProt

 P52429 (UniProt - Evidence at protein level)

neXtProt

 NX_P52429

Antibodypedia

 DGKE antibodies

PROTEIN BROWSER
DGKE-001
DGKE-002
DGKE-004
DGKE-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGKE-001
ENSP00000284061
ENST00000284061
P52429 [Direct mapping]
Diacylglycerol kinase epsilon
A1L4Q0 [Target identity:100%; Query identity:100%]
Diacylglycerol kinase
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008654 [phospholipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 567 aa
63.9 kDa 		No 1
DGKE-002
ENSP00000459295
ENST00000572810
P52429 [Direct mapping]
Diacylglycerol kinase epsilon
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008654 [phospholipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016310 [phosphorylation]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 177 aa
20.5 kDa 		No 1
DGKE-004
ENSP00000458493
ENST00000572944
I3L112 [Direct mapping]
Diacylglycerol kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 456 aa
51.1 kDa 		No 0
DGKE-006
ENSP00000459958
ENST00000570738
I3L2V2 [Direct mapping]
Diacylglycerol kinase epsilon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 70 aa
7.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.