Expression of HS2ST1 in cancer - Summary

CANCER ATLAS

Gene description

Heparan sulfate 2-O-sulfotransferase 1

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA043069	HPA043603

GENE INFORMATION
Gene name	HS2ST1 (HGNC Symbol)
Synonyms	KIAA0448
Description	Heparan sulfate 2-O-sulfotransferase 1 (HGNC Symbol)
Entrez gene summary	Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	1
Cytoband	p22.3
Chromosome location (bp)	86914648 - 87109998
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000153936 (version 83.38)
Entrez gene	9653
UniProt	Q7LGA3 (UniProt - Evidence at protein level)
neXtProt	NX_Q7LGA3
Antibodypedia	HS2ST1 antibodies

PROTEIN BROWSER

HS2ST1-001	HS2ST1-002	HS2ST1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HS2ST1-001 ENSP00000359581 ENST00000370550	Q7LGA3 [Direct mapping] Heparan sulfate 2-O-sulfotransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] Show all	356 aa 41.9 kDa	Yes	0
HS2ST1-002 ENSP00000359582 ENST00000370551	Q7LGA3 [Direct mapping] Heparan sulfate 2-O-sulfotransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] Show all	229 aa 26.8 kDa	Yes	0
HS2ST1-003 ENSP00000467253 ENST00000591456	K7EP71 [Direct mapping] Heparan sulfate 2-O-sulfotransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	111 aa 12.9 kDa	No	0