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HS3ST3A1

GENERAL INFORMATION

Gene name

 HS3ST3A1

Gene description

 Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Tissue enhanced (ovary)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA071530
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 HS3ST3A1 (HGNC Symbol)

Synonyms

 30ST3A1, 3OST3A1

Description

 Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (HGNC Symbol)

Entrez gene summary

 Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]

Chromosome

 17

Cytoband

 p12

Chromosome location (bp)

 13495689 - 13601927

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153976 (version 83.38)

Entrez gene

 9955

UniProt

 Q9Y663 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y663

Antibodypedia

 HS3ST3A1 antibodies

PROTEIN BROWSER
HS3ST3A1-001
HS3ST3A1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HS3ST3A1-001
ENSP00000284110
ENST00000284110
Q9Y663 [Direct mapping]
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
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GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0033872 [[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity]
GO:0044281 [small molecule metabolic process]
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 406 aa
44.9 kDa 		No 0
HS3ST3A1-002
ENSP00000462696
ENST00000578576
J3KSX5 [Direct mapping]
Sulfotransferase
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Predicted intracellular proteins
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GO:0008146 [sulfotransferase activity]
GO:0008152 [metabolic process]
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 204 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.