Expression of DNAAF1 in cancer - Summary

CANCER ATLAS

Gene description

Dynein, axonemal, assembly factor 1

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041166

GENE INFORMATION
Gene name	DNAAF1 (HGNC Symbol)
Synonyms	CILD13, FLJ25330, LRRC50, ODA7
Description	Dynein, axonemal, assembly factor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13.[provided by RefSeq, May 2010]
Chromosome	16
Cytoband	q24.1
Chromosome location (bp)	84145287 - 84178767
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154099 (version 83.38)
Entrez gene	123872
UniProt	Q8NEP3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEP3
Antibodypedia	DNAAF1 antibodies

PROTEIN BROWSER

DNAAF1-001	DNAAF1-008	DNAAF1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAAF1-001 ENSP00000367815 ENST00000378553	Q8NEP3 [Direct mapping] Dynein assembly factor 1, axonemal Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000922 [spindle pole] GO:0001947 [heart looping] GO:0003341 [cilium movement] GO:0003356 [regulation of cilium beat frequency] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005930 [axoneme] GO:0030324 [lung development] GO:0035469 [determination of pancreatic left/right asymmetry] GO:0036158 [outer dynein arm assembly] GO:0036159 [inner dynein arm assembly] GO:0044458 [motile cilium assembly] GO:0045502 [dynein binding] GO:0060271 [cilium morphogenesis] GO:0060287 [epithelial cilium movement involved in determination of left/right asymmetry] GO:0060972 [left/right pattern formation] GO:0070286 [axonemal dynein complex assembly] GO:0071907 [determination of digestive tract left/right asymmetry] GO:0071910 [determination of liver left/right asymmetry] Show all	725 aa 80 kDa	No	0
DNAAF1-008 ENSP00000457899 ENST00000564928	H3BV09 [Direct mapping] Dynein assembly factor 1, axonemal Show all	Predicted intracellular proteins Show all		58 aa 6.1 kDa	No	0
DNAAF1-009 ENSP00000454960 ENST00000569735	H3BNQ4 [Direct mapping] Dynein assembly factor 1, axonemal Show all	Predicted intracellular proteins Show all		190 aa 20.3 kDa	No	0