Expression of OTULIN in cancer - Summary

CANCER ATLAS

Gene description

OTU deubiquitinase with linear linkage specificity

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051074

GENE INFORMATION
Gene name	OTULIN (HGNC Symbol)
Synonyms	FAM105B, FLJ34884
Description	OTU deubiquitinase with linear linkage specificity (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p15.2
Chromosome location (bp)	14664664 - 14699711
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154124 (version 83.38)
Entrez gene	90268
UniProt	Q96BN8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BN8
Antibodypedia	OTULIN antibodies

PROTEIN BROWSER

OTULIN-001	OTULIN-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTULIN-001 ENSP00000284274 ENST00000284274	Q96BN8 [Direct mapping] Ubiquitin thioesterase otulin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002040 [sprouting angiogenesis] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007166 [cell surface receptor signaling pathway] GO:0008234 [cysteine-type peptidase activity] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0045087 [innate immune response] GO:0050728 [negative regulation of inflammatory response] GO:0060070 [canonical Wnt signaling pathway] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071797 [LUBAC complex] GO:1990108 [protein linear deubiquitination] Show all	352 aa 40.3 kDa	No	0
OTULIN-005 ENSP00000424966 ENST00000506417	H0Y9T0 [Direct mapping] Ubiquitin thioesterase otulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.7 kDa	No	0