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A majority of tumour cells displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Most cases of gliomas, lymphomas, renal and cervical cancers were weakly stained or negative.
Cancer tissues showed weak to moderate cytoplasmic positivity. Additional membranous positivity was seen in colorectal, prostate and pancreatic cancers. Thyroid cancers along with few cases of lymphomas and pancreatic cancers exhibited strong immunoreactivity. Gliomas, skin and cervical cancers along with some cases of urothelial and renal cancers were negative.
GENE INFORMATION
Gene name
UBASH3B (HGNC Symbol)
Synonyms
KIAA1959, STS-1, TULA2
Description
Ubiquitin associated and SH3 domain containing B (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Q8TF42 [Direct mapping] Ubiquitin-associated and SH3 domain-containing protein B
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006469 [negative regulation of protein kinase activity] GO:0009968 [negative regulation of signal transduction] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045670 [regulation of osteoclast differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0090331 [negative regulation of platelet aggregation]
