Cell atlas - FAM134B - The Human Protein Atlas

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FAM134B

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Nuclear bodies

Human cell
	Endoplasmic Reticulum
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FAM134B
Gene description	Family with sequence similarity 134, member B
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to the nuclear bodies.
RNA cell category	Cell line enhanced (SCLC-21H, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA012077
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to the nuclear bodies.

Main location

Endoplasmic reticulum (supported)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012077	HeLa	Nuclear bodies
	HPA012077	HeLa	Endoplasmic reticulum

GENE INFORMATION
Gene name	FAM134B (HGNC Symbol)
Synonyms	FLJ20152, JK1
Description	Family with sequence similarity 134, member B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cis-Golgi transmembrane protein that may be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Mutations in this gene are a cause of hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), and this gene may also play a role in susceptibility to vascular dementia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	5
Cytoband	p15.1
Chromosome location (bp)	16473038 - 16617058
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154153 (version 83.38)
Entrez gene	54463
UniProt	Q9H6L5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6L5
Antibodypedia	FAM134B antibodies

PROTEIN BROWSER

FAM134B-001	FAM134B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM134B-001 ENSP00000304642 ENST00000306320	Q9H6L5 [Direct mapping] Reticulophagy receptor FAM134B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0019233 [sensory perception of pain] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043524 [negative regulation of neuron apoptotic process] GO:0061709 [reticulophagy] Show all	497 aa 54.7 kDa	No	2
FAM134B-003 ENSP00000382691 ENST00000399793	Q9H6L5 [Direct mapping] Reticulophagy receptor FAM134B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0019233 [sensory perception of pain] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043524 [negative regulation of neuron apoptotic process] GO:0061709 [reticulophagy] Show all	356 aa 39.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.