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Most malignant cells showed a differentiated expression from strong to negative. Several cases of glioma, lymphomas, renal cell carcinomas and testicular cancer were negative.
GENE INFORMATION
Gene name
CDH12 (HGNC Symbol)
Synonyms
Br-cadherin, CDHB
Description
Cadherin 12, type 2 (N-cadherin 2) (HGNC Symbol)
Entrez gene summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]
