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GPR15

GENERAL INFORMATION

Gene name

 GPR15

Gene description

 G protein-coupled receptor 15

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (rectum, colon)
GTEx:Tissue enhanced (small intestine, colon)
FANTOM5:Group enriched (tonsil, lymph node, appendix, colon)

Protein evidence

 Evidence at transcript level

Protein expression

 Most abundant in a subset of immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA013775
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (rectum, colon)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, lymph node, appendix, colon)

GENE INFORMATION

Gene name

 GPR15

Synonyms

Description

 G protein-coupled receptor 15 (HGNC Symbol)

Entrez gene summary

 This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]

Chromosome

 3

Cytoband

 q11.2

Chromosome location (bp)

 98531899 - 98533150

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000154165 (version 83.38)

Entrez gene

 2838

UniProt

 P49685 (UniProt - Evidence at transcript level)

neXtProt

 NX_P49685

Antibodypedia

 GPR15 antibodies

PROTEIN BROWSER
GPR15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR15-001
ENSP00000284311
ENST00000284311
P49685 [Direct mapping]
G-protein coupled receptor 15
B6V9G9 [Target identity:100%; Query identity:100%]
G protein-coupled receptor 15
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0072678 [T cell migration]
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 360 aa
40.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.