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Cancer tissues displayed weak to moderate nuclear and cytoplasmic immunoreactivity. Hepatocellular carcinomas were strongly stained. Several renal cancers were negative.
A majority of cervical and colorectal cancers as well as several malignant lymphomas, cervical, endometrial, gastric and ovarian cancers displayed moderate cytoplasmic staining. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
CERS3 (HGNC Symbol)
Synonyms
LASS3, MGC27091
Description
Ceramide synthase 3 (HGNC Symbol)
Entrez gene summary
This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
