We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Moderate cytoplasmic immunoreactivity was observed in several cases of gliomas and lymphomas. Most remaining cancer tissues were weakly stained or negative.
A majority of cancer tissues displayed weak to moderate cytoplasmic immunoreactivity. Squamous cell carcinomas, breast cancers and testicular cancers were in general negative.
Strong cytoplasmic immunoreactivity was observed in most gliomas. Most remaining cancer tissues negative.
GENE INFORMATION
Gene name
PRKCA (HGNC Symbol)
Synonyms
PKCA
Description
Protein kinase C, alpha (HGNC Symbol)
Entrez gene summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
P17252 [Direct mapping] Protein kinase C alpha type L7RSM7 [Target identity:100%; Query identity:100%] Protein kinase C
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000188 [inactivation of MAPK activity] GO:0000278 [mitotic cell cycle] GO:0001525 [angiogenesis] GO:0001750 [photoreceptor outer segment] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002026 [regulation of the force of heart contraction] GO:0002062 [chondrocyte differentiation] GO:0002159 [desmosome assembly] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004698 [calcium-dependent protein kinase C activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006874 [cellular calcium ion homeostasis] GO:0006937 [regulation of muscle contraction] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0007603 [phototransduction, visible light] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0010595 [positive regulation of endothelial cell migration] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0016020 [membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0019899 [enzyme binding] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030335 [positive regulation of cell migration] GO:0030425 [dendrite] GO:0030593 [neutrophil chemotaxis] GO:0031666 [positive regulation of lipopolysaccharide-mediated signaling pathway] GO:0031966 [mitochondrial membrane] GO:0034351 [negative regulation of glial cell apoptotic process] GO:0035403 [histone kinase activity (H3-T6 specific)] GO:0035408 [histone H3-T6 phosphorylation] GO:0035556 [intracellular signal transduction] GO:0036289 [peptidyl-serine autophosphorylation] GO:0043025 [neuronal cell body] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0045651 [positive regulation of macrophage differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046325 [negative regulation of glucose import] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050729 [positive regulation of inflammatory response] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050796 [regulation of insulin secretion] GO:0050930 [induction of positive chemotaxis] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070555 [response to interleukin-1] GO:0071322 [cellular response to carbohydrate stimulus] GO:0090330 [regulation of platelet aggregation] GO:0097190 [apoptotic signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway] GO:2000707 [positive regulation of dense core granule biogenesis]