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Malignant tissues exhibited weak to moderate cytoplasmic and occasional membranous immunoreactivity. Many cases of malignant melanomas, malignant gliomas, lung, testicular, renal and liver cancers were negative.
GENE INFORMATION
Gene name
CEP112 (HGNC Symbol)
Synonyms
CCDC46, MGC33887
Description
Centrosomal protein 112kDa (HGNC Symbol)
Entrez gene summary
This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
