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ENPP3

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GENERAL INFORMATION

Gene name

 ENPP3

Gene description

 Ectonucleotide pyrophosphatase/phosphodiesterase 3

Protein class

 CD markers
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (Hep G2, HMC-1, HEL)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, HMC-1, HEL)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ENPP3 (HGNC Symbol)

Synonyms

 B10, CD203c, gp130RB13-6, PD-IBETA, PDNP3

Description

 Ectonucleotide pyrophosphatase/phosphodiesterase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 6

Cytoband

 q23.2

Chromosome location (bp)

 131628442 - 131747418

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154269 (version 83.38)

Entrez gene

 5169

UniProt

 O14638 (UniProt - Evidence at protein level)

neXtProt

 NX_O14638

Antibodypedia

 ENPP3 antibodies

PROTEIN BROWSER
ENPP3-001
ENPP3-201
ENPP3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENPP3-001
ENSP00000406261
ENST00000414305
O14638 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Alkaline phosphodiesterase I Nucleotide pyrophosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0005044 [scavenger receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0009143 [nucleoside triphosphate catabolic process]
GO:0016787 [hydrolase activity]
GO:0030247 [polysaccharide binding]
GO:0035529 [NADH pyrophosphatase activity]
GO:0046872 [metal ion binding]
GO:0047429 [nucleoside-triphosphate diphosphatase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 875 aa
100.1 kDa 		No 0
ENPP3-201
ENSP00000350265
ENST00000357639
O14638 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Alkaline phosphodiesterase I Nucleotide pyrophosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0005044 [scavenger receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0009143 [nucleoside triphosphate catabolic process]
GO:0016787 [hydrolase activity]
GO:0030247 [polysaccharide binding]
GO:0035529 [NADH pyrophosphatase activity]
GO:0046872 [metal ion binding]
GO:0047429 [nucleoside-triphosphate diphosphatase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 875 aa
100.1 kDa 		No 0
ENPP3-202
ENSP00000350964
ENST00000358229
F8W6H5 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0005044 [scavenger receptor activity]
GO:0005886 [plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0030247 [polysaccharide binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 663 aa
76 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.