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TNIK

GENERAL INFORMATION

Gene name

 TNIK

Gene description

 TRAF2 and NCK interacting kinase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA012128 , HPA012297
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TNIK (HGNC Symbol)

Synonyms

 KIAA0551

Description

 TRAF2 and NCK interacting kinase (HGNC Symbol)

Entrez gene summary

 Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]

Chromosome

 3

Cytoband

Chromosome location (bp)

 171061339 - 171460408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154310 (version 83.38)

Entrez gene

 23043

UniProt

 Q9UKE5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKE5

Antibodypedia

 TNIK antibodies

PROTEIN BROWSER
TNIK-001
TNIK-002
TNIK-003
TNIK-004
TNIK-005
TNIK-006
TNIK-007
TNIK-008
TNIK-009
TNIK-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNIK-001
ENSP00000399511
ENST00000436636
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1360 aa
154.9 kDa 		No 0
TNIK-002
ENSP00000419308
ENST00000465393
C9JVV1 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0005622 [intracellular]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0048812 [neuron projection morphogenesis]
Show all
 45 aa
4.9 kDa 		No 0
TNIK-003
ENSP00000345352
ENST00000341852
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1276 aa
145.2 kDa 		No 0
TNIK-004
ENSP00000284483
ENST00000284483
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1352 aa
154 kDa 		No 0
TNIK-005
ENSP00000418156
ENST00000475336
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1268 aa
144.3 kDa 		No 0
TNIK-006
ENSP00000349880
ENST00000357327
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1331 aa
151.3 kDa 		No 0
TNIK-007
ENSP00000418916
ENST00000460047
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1297 aa
147.9 kDa 		No 0
TNIK-008
ENSP00000418378
ENST00000488470
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1305 aa
148.8 kDa 		No 0
TNIK-009
ENSP00000419990
ENST00000470834
Q9UKE5 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007256 [activation of JNKK activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
Show all
 1323 aa
150.4 kDa 		No 0
TNIK-012
ENSP00000417338
ENST00000468757
C9J338 [Direct mapping]
TRAF2 and NCK-interacting protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0048812 [neuron projection morphogenesis]
Show all
 350 aa
40.4 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.