Expression of TMPRSS15 in cancer - Summary

CANCER ATLAS

Gene description

Transmembrane protease, serine 15

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015611

GENE INFORMATION
Gene name	TMPRSS15 (HGNC Symbol)
Synonyms	ENTK, MGC133046, PRSS7
Description	Transmembrane protease, serine 15 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q21.1
Chromosome location (bp)	18269116 - 18485879
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154646 (version 83.38)
Entrez gene	5651
UniProt	P98073 (UniProt - Evidence at protein level)
neXtProt	NX_P98073
Antibodypedia	TMPRSS15 antibodies

PROTEIN BROWSER

TMPRSS15-001	TMPRSS15-002	TMPRSS15-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMPRSS15-001 ENSP00000284885 ENST00000284885	P98073 [Direct mapping] Enteropeptidase Enteropeptidase non-catalytic heavy chain Enteropeptidase catalytic light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005903 [brush border] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1019 aa 112.9 kDa	No	0
TMPRSS15-002 ENSP00000398253 ENST00000422787	E9PG70 [Direct mapping] Enteropeptidase Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	228 aa 25 kDa	No	0
TMPRSS15-003 ENSP00000474811 ENST00000474775		Predicted intracellular proteins Show all		5 aa 0.5 kDa	No	0