Tissue expression of PDE1C - Summary - The Human Protein Atlas

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PDE1C

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PDE1C
Gene description	Phosphodiesterase 1C, calmodulin-dependent 70kDa
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (heart muscle)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (heart muscle)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA021751 , HPA052375
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (heart muscle)

GENE INFORMATION
Gene name	PDE1C (HGNC Symbol)
Synonyms	Hcam3
Description	Phosphodiesterase 1C, calmodulin-dependent 70kDa (HGNC Symbol)
Entrez gene summary	Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	31751179 - 32299329
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154678 (version 83.38)
Entrez gene	5137
UniProt	Q14123 (UniProt - Evidence at protein level)
neXtProt	NX_Q14123
Antibodypedia	PDE1C antibodies

PROTEIN BROWSER

PDE1C-001	PDE1C-002	PDE1C-003	PDE1C-004	PDE1C-006	PDE1C-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE1C-001 ENSP00000379496 ENST00000396193	A0A0A0MS69 [Direct mapping] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005929 [cilium] GO:0007165 [signal transduction] GO:0007608 [sensory perception of smell] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	769 aa 86.9 kDa	No	0
PDE1C-002 ENSP00000318105 ENST00000321453	Q14123 [Direct mapping] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	709 aa 80.8 kDa	No	0
PDE1C-003 ENSP00000379487 ENST00000396184	Q14123 [Direct mapping] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	634 aa 72.2 kDa	No	0
PDE1C-004 ENSP00000379492 ENST00000396189	F8W905 [Direct mapping] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 5.7 kDa	No	0
PDE1C-006 ENSP00000379494 ENST00000396191	Q14123 [Direct mapping] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	709 aa 80.8 kDa	No	0
PDE1C-007 ENSP00000379485 ENST00000396182	Q14123 [Direct mapping] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	634 aa 72.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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