Expression of MRPL39 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein L39

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018331

GENE INFORMATION
Gene name	MRPL39 (HGNC Symbol)
Synonyms	C21orf92, FLJ20451, L39mt, MGC104174, MGC3400, MRP-L5, MSTP003, PRED22, PRED66, RPML5
Description	Mitochondrial ribosomal protein L39 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q21.3
Chromosome location (bp)	25585656 - 25607517
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154719 (version 83.38)
Entrez gene	54148
UniProt	Q9NYK5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYK5
Antibodypedia	MRPL39 antibodies

PROTEIN BROWSER

MRPL39-001	MRPL39-002	MRPL39-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL39-001 ENSP00000284967 ENST00000352957	Q9NYK5 [Direct mapping] 39S ribosomal protein L39, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	338 aa 38.7 kDa	No	0
MRPL39-002 ENSP00000305682 ENST00000307301	Q9NYK5 [Direct mapping] 39S ribosomal protein L39, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	353 aa 40.5 kDa	No	0
MRPL39-003 ENSP00000404426 ENST00000419219	C9JG87 [Direct mapping] 39S ribosomal protein L39, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] Show all	297 aa 34 kDa	No	0