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ATP5J

GENERAL INFORMATION

Gene name

 ATP5J

Gene description

 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA031069
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATP5J (HGNC Symbol)

Synonyms

 ATP5, ATP5A, ATPM, CF6

Description

 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (HGNC Symbol)

Entrez gene summary

 Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11.[provided by RefSeq, Jun 2010]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 25716503 - 25735673

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154723 (version 83.38)

Entrez gene

 522

UniProt

 P18859 (UniProt - Evidence at protein level)

neXtProt

 NX_P18859

Antibodypedia

 ATP5J antibodies

PROTEIN BROWSER
ATP5J-001
ATP5J-002
ATP5J-003
ATP5J-004
ATP5J-005
ATP5J-006
ATP5J-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5J-001
ENSP00000284971
ENST00000284971
P18859 [Direct mapping]
ATP synthase-coupling factor 6, mitochondrial
Q6IB54 [Target identity:100%; Query identity:100%]
ATP synthase-coupling factor 6, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0005215 [transporter activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0021762 [substantia nigra development]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 108 aa
12.6 kDa 		No 0
ATP5J-002
ENSP00000382965
ENST00000400093
P18859 [Direct mapping]
ATP synthase-coupling factor 6, mitochondrial
Q6IB54 [Target identity:100%; Query identity:100%]
ATP synthase-coupling factor 6, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0005215 [transporter activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0021762 [substantia nigra development]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 108 aa
12.6 kDa 		No 0
ATP5J-003
ENSP00000389649
ENST00000457143
P18859 [Direct mapping]
ATP synthase-coupling factor 6, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0005215 [transporter activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0021762 [substantia nigra development]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046034 [ATP metabolic process]
Show all
 116 aa
13.4 kDa 		No 0
ATP5J-004
ENSP00000382971
ENST00000400099
A8MUH2 [Direct mapping]
ATP synthase-coupling factor 6, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0005739 [mitochondrion]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
Show all
 119 aa
14 kDa 		No 0
ATP5J-005
ENSP00000382962
ENST00000400090
P18859 [Direct mapping]
ATP synthase-coupling factor 6, mitochondrial
Q6IB54 [Target identity:100%; Query identity:100%]
ATP synthase-coupling factor 6, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0005215 [transporter activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0021762 [substantia nigra development]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 108 aa
12.6 kDa 		No 0
ATP5J-006
ENSP00000382959
ENST00000400087
P18859 [Direct mapping]
ATP synthase-coupling factor 6, mitochondrial
Q6IB54 [Target identity:100%; Query identity:100%]
ATP synthase-coupling factor 6, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0005215 [transporter activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0021762 [substantia nigra development]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 108 aa
12.6 kDa 		No 0
ATP5J-007
ENSP00000382966
ENST00000400094
P18859 [Direct mapping]
ATP synthase-coupling factor 6, mitochondrial
Q6IB54 [Target identity:100%; Query identity:100%]
ATP synthase-coupling factor 6, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0005215 [transporter activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0021762 [substantia nigra development]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 108 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.