Expression of ADAMTS5 in cancer - Summary

CANCER ATLAS

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 5

Protein class

Cancer-related genes, Enzymes, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA005661	CAB025996

GENE INFORMATION
Gene name	ADAMTS5 (HGNC Symbol)
Synonyms	ADAMTS11, ADMP-2
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q21.3
Chromosome location (bp)	26917912 - 26966513
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154736 (version 83.38)
Entrez gene	11096
UniProt	Q9UNA0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNA0
Antibodypedia	ADAMTS5 antibodies

PROTEIN BROWSER

ADAMTS5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS5-001 ENSP00000284987 ENST00000284987	Q9UNA0 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 5 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0042742 [defense response to bacterium] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	930 aa 101.7 kDa	Yes	0