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TSEN2

CANCER ATLAS

Gene description

 TSEN2 tRNA splicing endonuclease subunit

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027120
HPA027125
HPA027268

GENE INFORMATION

Gene name

 TSEN2 (HGNC Symbol)

Synonyms

 MGC2776, SEN2, SEN2L

Description

 TSEN2 tRNA splicing endonuclease subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

Chromosome

 3

Cytoband

 p25.2

Chromosome location (bp)

 12484432 - 12539623

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154743 (version 83.38)

Entrez gene

 80746

UniProt

 Q8NCE0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NCE0

Antibodypedia

 TSEN2 antibodies

PROTEIN BROWSER
TSEN2-001
TSEN2-002
TSEN2-003
TSEN2-004
TSEN2-006
TSEN2-008
TSEN2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSEN2-001
ENSP00000284995
ENST00000284995
Q8NCE0 [Direct mapping]
tRNA-splicing endonuclease subunit Sen2
A0A024R2H2 [Target identity:100%; Query identity:100%]
tRNA-splicing endonuclease subunit Sen2
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 465 aa
53.2 kDa 		No 0
TSEN2-002
ENSP00000385976
ENST00000402228
Q8NCE0 [Direct mapping]
tRNA-splicing endonuclease subunit Sen2
A0A024R2H2 [Target identity:100%; Query identity:100%]
tRNA-splicing endonuclease subunit Sen2
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 465 aa
53.2 kDa 		No 0
TSEN2-003
ENSP00000392029
ENST00000454502
Q8NCE0 [Direct mapping]
tRNA-splicing endonuclease subunit Sen2
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 406 aa
47.1 kDa 		No 0
TSEN2-004
ENSP00000406238
ENST00000446004
C9J7Z4 [Direct mapping]
tRNA-splicing endonuclease subunit Sen2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 378 aa
43.2 kDa 		No 0
TSEN2-006
ENSP00000416510
ENST00000415684
Q8NCE0 [Direct mapping]
tRNA-splicing endonuclease subunit Sen2
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 439 aa
49.9 kDa 		No 0
TSEN2-008
ENSP00000408528
ENST00000412698
H7C2Z3 [Direct mapping]
tRNA-splicing endonuclease subunit Sen2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 101 aa
11.3 kDa 		No 0
TSEN2-201
ENSP00000407974
ENST00000444864
Q8NCE0 [Direct mapping]
tRNA-splicing endonuclease subunit Sen2
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016829 [lyase activity]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 402 aa
45.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.