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DPH3

CANCER ATLAS

Gene description

 Diphthamide biosynthesis 3

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035287

GENE INFORMATION

Gene name

 DPH3 (HGNC Symbol)

Synonyms

 DELGIP, DELGIP1, DESR1, DPH3A, KTI11, MGC20197, ZCSL2

Description

 Diphthamide biosynthesis 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 16257978 - 16264972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000154813 (version 83.38)

Entrez gene

 285381

UniProt

 Q96FX2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96FX2

Antibodypedia

 DPH3 antibodies

PROTEIN BROWSER
DPH3-001
DPH3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPH3-001
ENSP00000419599
ENST00000488423
Q96FX2 [Direct mapping]
DPH3 homolog
A0A024R2P5 [Target identity:100%; Query identity:100%]
Zinc finger, CSL-type containing 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0050709 [negative regulation of protein secretion]
GO:0051099 [positive regulation of binding]
Show all
 82 aa
9.2 kDa 		No 0
DPH3-002
ENSP00000373285
ENST00000383775
Q96FX2 [Direct mapping]
DPH3 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0050709 [negative regulation of protein secretion]
GO:0051099 [positive regulation of binding]
Show all
 57 aa
6.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.