Cell atlas - APCDD1 - The Human Protein Atlas

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APCDD1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	APCDD1
Gene description	Adenomatosis polyposis coli down-regulated 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (BJ hTERT+, HaCaT, AF22)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BJ hTERT+, HaCaT, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	APCDD1 (HGNC Symbol)
Synonyms	B7323
Description	Adenomatosis polyposis coli down-regulated 1 (HGNC Symbol)
Entrez gene summary	This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]
Chromosome	18
Cytoband	p11.22
Chromosome location (bp)	10454628 - 10489948
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154856 (version 83.38)
Entrez gene	147495
UniProt	Q8J025 (UniProt - Evidence at protein level)
neXtProt	NX_Q8J025
Antibodypedia	APCDD1 antibodies

PROTEIN BROWSER

APCDD1-001	APCDD1-004	APCDD1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APCDD1-001 ENSP00000347433 ENST00000355285	Q8J025 [Direct mapping] Protein APCDD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001942 [hair follicle development] GO:0005887 [integral component of plasma membrane] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0043615 [astrocyte cell migration] Show all	514 aa 58.8 kDa	Yes	1
APCDD1-004 ENSP00000463104 ENST00000578882	J3KTQ6 [Direct mapping] Protein APCDD1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 21.4 kDa	Yes	0
APCDD1-006 ENSP00000476491 ENST00000584596	V9GY82 [Direct mapping] Protein APCDD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		227 aa 25.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.