Tissue expression of MPPE1 - Summary - The Human Protein Atlas

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MPPE1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MPPE1
Gene description	Metallophosphoesterase 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA012639
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MPPE1
Synonyms
Description	Metallophosphoesterase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	p11.21
Chromosome location (bp)	11882622 - 11909223
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000154889 (version 83.38)
Entrez gene	65258
UniProt	Q53F39 (UniProt - Evidence at protein level)
neXtProt	NX_Q53F39
Antibodypedia	MPPE1 antibodies

PROTEIN BROWSER

MPPE1-001	MPPE1-004	MPPE1-008	MPPE1-010	MPPE1-011	MPPE1-012	MPPE1-015	MPPE1-016	MPPE1-017	MPPE1-021	MPPE1-023	MPPE1-024	MPPE1-028	MPPE1-029

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPPE1-001 ENSP00000465894 ENST00000588072	Q53F39 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0006506 [GPI anchor biosynthetic process] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008081 [phosphoric diester hydrolase activity] GO:0016021 [integral component of membrane] GO:0030145 [manganese ion binding] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0034235 [GPI anchor binding] GO:0070971 [endoplasmic reticulum exit site] Show all	396 aa 45.1 kDa	No	2
MPPE1-004 ENSP00000327257 ENST00000317235	Q53F39 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0006506 [GPI anchor biosynthetic process] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008081 [phosphoric diester hydrolase activity] GO:0016021 [integral component of membrane] GO:0030145 [manganese ion binding] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0034235 [GPI anchor binding] GO:0070971 [endoplasmic reticulum exit site] Show all	333 aa 38.3 kDa	No	2
MPPE1-008 ENSP00000311200 ENST00000309976	Q53F39 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0006506 [GPI anchor biosynthetic process] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008081 [phosphoric diester hydrolase activity] GO:0016021 [integral component of membrane] GO:0030145 [manganese ion binding] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0034235 [GPI anchor binding] GO:0070971 [endoplasmic reticulum exit site] Show all	333 aa 38.3 kDa	No	2
MPPE1-010 ENSP00000465318 ENST00000589267	K7EJU0 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	141 aa 16.5 kDa	No	1
MPPE1-011 ENSP00000467993 ENST00000588186	K7EQV4 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	178 aa 21 kDa	No	1
MPPE1-012 ENSP00000467698 ENST00000588191	K7EQ70 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	164 aa 19.2 kDa	No	1
MPPE1-015 ENSP00000468065 ENST00000588103	K7ER13 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	92 aa 10.6 kDa	No	1
MPPE1-016 ENSP00000339423 ENST00000344987	A0A0A0MR93 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	374 aa 43 kDa	No	2
MPPE1-017 ENSP00000468269 ENST00000586844	K7ERI3 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	69 aa 7.9 kDa	No	1
MPPE1-021 ENSP00000468639 ENST00000590501	K7ESB8 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	94 aa 10.9 kDa	No	1
MPPE1-023 ENSP00000468606 ENST00000592977	K7ES91 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	308 aa 35.4 kDa	No	1
MPPE1-024 ENSP00000467703 ENST00000589859	K7EQ74 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	70 aa 8.1 kDa	No	1
MPPE1-028 ENSP00000466303 ENST00000592331	K7EM03 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	172 aa 19.5 kDa	No	0
MPPE1-029 ENSP00000466291 ENST00000587724	K7ELZ7 [Direct mapping] Metallophosphoesterase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.