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DKK2

GENERAL INFORMATION

Gene name

 DKK2

Gene description

 Dickkopf WNT signaling pathway inhibitor 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, most abundant in squamous epithelial.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
CAB009727
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)

GENE INFORMATION

Gene name

 DKK2

Synonyms

Description

 Dickkopf WNT signaling pathway inhibitor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 106921802 - 107283806

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155011 (version 83.38)

Entrez gene

 27123

UniProt

 Q9UBU2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UBU2

Antibodypedia

 DKK2 antibodies

PROTEIN BROWSER
DKK2-001
DKK2-003
DKK2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DKK2-001
ENSP00000285311
ENST00000285311
Q9UBU2 [Direct mapping]
Dickkopf-related protein 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007275 [multicellular organismal development]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 259 aa
28.4 kDa 		Yes 0
DKK2-003
ENSP00000421255
ENST00000513208
D6RGF1 [Direct mapping]
Dickkopf-related protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0007275 [multicellular organismal development]
GO:0030178 [negative regulation of Wnt signaling pathway]
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 159 aa
18.1 kDa 		No 0
DKK2-004
ENSP00000423797
ENST00000510463
D6RCC2 [Direct mapping]
Dickkopf-related protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0007275 [multicellular organismal development]
GO:0030178 [negative regulation of Wnt signaling pathway]
Show all
 213 aa
24 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.