Tissue expression of KLF10 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KLF10
Gene description	Kruppel-like factor 10
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	KLF10 (HGNC Symbol)
Synonyms	EGRA, TIEG, TIEG1
Description	Kruppel-like factor 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	102648779 - 102655902
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155090 (version 83.38)
Entrez gene	7071
UniProt	Q13118 (UniProt - Evidence at protein level)
neXtProt	NX_Q13118
Antibodypedia	KLF10 antibodies

PROTEIN BROWSER

KLF10-001	KLF10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLF10-001 ENSP00000285407 ENST00000285407	Q13118 [Direct mapping] Krueppel-like factor 10 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001501 [skeletal system development] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007623 [circadian rhythm] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009267 [cellular response to starvation] GO:0030282 [bone mineralization] GO:0035019 [somatic stem cell population maintenance] GO:0042752 [regulation of circadian rhythm] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:1901653 [cellular response to peptide] Show all	480 aa 52.6 kDa	No	0
KLF10-002 ENSP00000379222 ENST00000395884	Q13118 [Direct mapping] Krueppel-like factor 10 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001501 [skeletal system development] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009267 [cellular response to starvation] GO:0042752 [regulation of circadian rhythm] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	469 aa 51.4 kDa	No	0