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Moderate to strong cytoplasmic immunoreactivity was observed in melanomas and thyroid cancers while several cases of lymphomas, liver, gastric, endometrial and colorectal cancers were moderately stained. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
PI4K2A (HGNC Symbol)
Synonyms
DKFZP761G1923, PI4KII, PIK42A
Description
Phosphatidylinositol 4-kinase type 2 alpha (HGNC Symbol)
Entrez gene summary
Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]