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DBI

CANCER ATLAS

Gene description

 Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)

Protein class

 Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA051428

GENE INFORMATION

Gene name

 DBI (HGNC Symbol)

Synonyms

 ACBD1, ACBP

Description

 Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) (HGNC Symbol)

Entrez gene summary

 This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.2

Chromosome location (bp)

 119366921 - 119372560

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155368 (version 83.38)

Entrez gene

 1622

UniProt

 P07108 (UniProt - Evidence at protein level)

neXtProt

 NX_P07108

Antibodypedia

 DBI antibodies

PROTEIN BROWSER
DBI-001
DBI-002
DBI-003
DBI-006
DBI-008
DBI-009
DBI-201
DBI-202
DBI-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DBI-001
ENSP00000348116
ENST00000355857
P07108 [Direct mapping]
Acyl-CoA-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0030156 [benzodiazepine receptor binding]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 87 aa
10 kDa 		No 0
DBI-002
ENSP00000311117
ENST00000311521
P07108 [Direct mapping]
Acyl-CoA-binding protein
A0A024RAF2 [Target identity:100%; Query identity:100%]
Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0030156 [benzodiazepine receptor binding]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 104 aa
11.8 kDa 		No 0
DBI-003
ENSP00000376815
ENST00000393103
P07108 [Direct mapping]
Acyl-CoA-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0030156 [benzodiazepine receptor binding]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 88 aa
10.1 kDa 		No 0
DBI-006
ENSP00000386486
ENST00000409094
P07108 [Direct mapping]
Acyl-CoA-binding protein
A0A024RAF2 [Target identity:100%; Query identity:100%]
Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0030156 [benzodiazepine receptor binding]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 104 aa
11.8 kDa 		No 0
DBI-008
ENSP00000486361
ENST00000627305
P07108 [Direct mapping]
Acyl-CoA-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0001662 [behavioral fear response]
GO:0001942 [hair follicle development]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006641 [triglyceride metabolic process]
GO:0006810 [transport]
GO:0007611 [learning or memory]
GO:0008289 [lipid binding]
GO:0021670 [lateral ventricle development]
GO:0030156 [benzodiazepine receptor binding]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0043588 [skin development]
GO:0046983 [protein dimerization activity]
GO:0060291 [long-term synaptic potentiation]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 148 aa
16.5 kDa 		No 0
DBI-009
ENSP00000486281
ENST00000627093
P07108 [Direct mapping]
Acyl-CoA-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0030156 [benzodiazepine receptor binding]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 129 aa
14.4 kDa 		No 0
DBI-201
ENSP00000442917
ENST00000535617
B8ZWD1 [Direct mapping]
Acyl-CoA-binding protein; Diazepam binding inhibitor, splice form 1A(2)
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
Show all
 97 aa
11.1 kDa 		No 0
DBI-202
ENSP00000439012
ENST00000535757
P07108 [Direct mapping]
Acyl-CoA-binding protein
A0A024RAF2 [Target identity:100%; Query identity:100%]
Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0030156 [benzodiazepine receptor binding]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 104 aa
11.8 kDa 		No 0
DBI-203
ENSP00000440698
ENST00000542275
A0A0A0MTI5 [Direct mapping]
Acyl-CoA-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
Show all
 143 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.