Fields »
ABOUT
HELP
BLOG
CNOT8

CANCER ATLAS

Gene description

 CCR4-NOT transcription complex, subunit 8

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA051398

GENE INFORMATION

Gene name

 CNOT8 (HGNC Symbol)

Synonyms

 CAF1, CALIF, hCAF1, POP2

Description

 CCR4-NOT transcription complex, subunit 8 (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q33.2

Chromosome location (bp)

 154857553 - 154876793

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155508 (version 83.38)

Entrez gene

 9337

UniProt

 Q9UFF9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UFF9

Antibodypedia

 CNOT8 antibodies

PROTEIN BROWSER
«
CNOT8-001
CNOT8-002
CNOT8-003
CNOT8-004
CNOT8-005
CNOT8-006
CNOT8-007
CNOT8-008
CNOT8-010
CNOT8-011
CNOT8-012
CNOT8-013
CNOT8-014
CNOT8-015
CNOT8-018
CNOT8-019
CNOT8-021
CNOT8-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNOT8-001
ENSP00000285896
ENST00000285896
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 292 aa
33.5 kDa 		No 0
CNOT8-002
ENSP00000429576
ENST00000524105
B7Z9U0 [Direct mapping]
CCR4-NOT transcription complex subunit 8; cDNA, FLJ78954, highly similar to CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 128 aa
14.7 kDa 		No 0
CNOT8-003
ENSP00000430833
ENST00000519404
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 238 aa
27.4 kDa 		No 0
CNOT8-004
ENSP00000428565
ENST00000523698
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 186 aa
21.2 kDa 		No 0
CNOT8-005
ENSP00000431034
ENST00000521450
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 186 aa
21.2 kDa 		No 0
CNOT8-006
ENSP00000430493
ENST00000517876
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 292 aa
33.5 kDa 		No 0
CNOT8-007
ENSP00000428305
ENST00000520671
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 186 aa
21.2 kDa 		No 0
CNOT8-008
ENSP00000429882
ENST00000521583
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 186 aa
21.2 kDa 		No 0
CNOT8-010
ENSP00000384747
ENST00000403027
Q9UFF9 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 292 aa
33.5 kDa 		No 0
CNOT8-011
ENSP00000430215
ENST00000520472
E5RGE4 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 133 aa
15.4 kDa 		No 0
CNOT8-012
ENSP00000428359
ENST00000519903
E5RIU0 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 85 aa
9.9 kDa 		No 0
CNOT8-013
ENSP00000429108
ENST00000519211
E5RJC5 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 119 aa
13.8 kDa 		No 0
CNOT8-014
ENSP00000428550
ENST00000522458
E5RHP3 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 121 aa
14 kDa 		No 0
CNOT8-015
ENSP00000428090
ENST00000517568
A0A0E3D6L6 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 118 aa
13.7 kDa 		No 0
CNOT8-018
ENSP00000429810
ENST00000518028
E5RHG0 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 55 aa
6.3 kDa 		No 0
CNOT8-019
ENSP00000429310
ENST00000519430
E5RHG0 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 55 aa
6.3 kDa 		No 0
CNOT8-021
ENSP00000428842
ENST00000519394
E5RFJ4 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 90 aa
10.4 kDa 		No 0
CNOT8-024
ENSP00000429394
ENST00000518775
E5RIL2 [Direct mapping]
CCR4-NOT transcription complex subunit 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 225 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.