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Weak to moderate cytoplasmic immunoreactivity was observed in most cancer tissues. Lymphomas, several squamous cell carcinomas and few renal cancers were negative.
Thyroid cancers, several cases of colorectal pancreas and prostate cancers along with few cases of melanomas, duct carcinomas of breast, ovary, endometrial, liver and stomach cancers showed moderate positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
XAGE2 (HGNC Symbol)
Synonyms
CT12.2, GAGED3, XAGE-2, XAGE2B
Description
X antigen family, member 2 (HGNC Symbol)
Entrez gene summary
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
