We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Malignant cells were generally negative. Isolated cases of squamous cell carcinomas showed weak to moderate positivity.
GENE INFORMATION
Gene name
OTOA (HGNC Symbol)
Synonyms
CT108, DFNB22
Description
Otoancorin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
