Tissue expression of FZD7 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FZD7
Gene description	Frizzled class receptor 7
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	FZD7 (HGNC Symbol)
Synonyms	FzE3
Description	Frizzled class receptor 7 (HGNC Symbol)
Entrez gene summary	Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	202034587 - 202038445
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155760 (version 83.38)
Entrez gene	8324
UniProt	O75084 (UniProt - Evidence at protein level)
neXtProt	NX_O75084
Antibodypedia	FZD7 antibodies

PROTEIN BROWSER

FZD7-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FZD7-001 ENSP00000286201 ENST00000286201	O75084 [Direct mapping] Frizzled-7 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family fz/smo receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005109 [frizzled binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0010812 [negative regulation of cell-substrate adhesion] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017147 [Wnt-protein binding] GO:0019827 [stem cell population maintenance] GO:0030165 [PDZ domain binding] GO:0030182 [neuron differentiation] GO:0033077 [T cell differentiation in thymus] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035412 [regulation of catenin import into nucleus] GO:0035567 [non-canonical Wnt signaling pathway] GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade] GO:0042327 [positive regulation of phosphorylation] GO:0042666 [negative regulation of ectodermal cell fate specification] GO:0042813 [Wnt-activated receptor activity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046330 [positive regulation of JNK cascade] GO:0048103 [somatic stem cell division] GO:0060054 [positive regulation of epithelial cell proliferation involved in wound healing] GO:0060070 [canonical Wnt signaling pathway] GO:0060231 [mesenchymal to epithelial transition] GO:0071300 [cellular response to retinoic acid] Show all	574 aa 63.6 kDa	Yes	7