Cell atlas - SLC26A2 - The Human Protein Atlas

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SLC26A2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SLC26A2
Gene description	Solute carrier family 26 (anion exchanger), member 2
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041957
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041957	A-431	No staining
	HPA041957	U-251 MG	Vesicles

GENE INFORMATION
Gene name	SLC26A2 (HGNC Symbol)
Synonyms	DTD, DTDST
Description	Solute carrier family 26 (anion exchanger), member 2 (HGNC Symbol)
Entrez gene summary	The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	149960737 - 149993455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155850 (version 83.38)
Entrez gene	1836
UniProt	P50443 (UniProt - Evidence at protein level)
neXtProt	NX_P50443
Antibodypedia	SLC26A2 antibodies

PROTEIN BROWSER

SLC26A2-001	SLC26A2-002	SLC26A2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC26A2-001 ENSP00000286298 ENST00000286298	P50443 [Direct mapping] Sulfate transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0006811 [ion transport] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0030203 [glycosaminoglycan metabolic process] GO:0042391 [regulation of membrane potential] GO:0044281 [small molecule metabolic process] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	739 aa 81.7 kDa	No	>9
SLC26A2-002 ENSP00000405496 ENST00000433184	C9JAN6 [Direct mapping] Sulfate transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.6 kDa	No	0
SLC26A2-003 ENSP00000426053 ENST00000503336	H0YA38 [Direct mapping] Sulfate transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	124 aa 13.2 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.