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Malignant tissues displayed weak staining or negative cells in most cases. Hepatocellular, colorectal, endometrial, prostate and pancreatic cancers displayed moderate cytoplasmic immunoreactivity in a majority of cases.
Colorectal malignancies exhibited strong cytoplasmic and membranous staining. Most malignant lymphomas and prostate cancers were negative. Most other malignancies showed weak to moderate staining.
GENE INFORMATION
Gene name
ADCY8 (HGNC Symbol)
Synonyms
AC8, ADCY3, HBAC1
Description
Adenylate cyclase 8 (brain) (HGNC Symbol)
Entrez gene summary
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]