We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013]
O15247 [Direct mapping] Chloride intracellular channel protein 2
Show all
Transporters Transporter channels and pores Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004602 [glutathione peroxidase activity] GO:0005244 [voltage-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006810 [transport] GO:0007165 [signal transduction] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0034707 [chloride channel complex] GO:0051099 [positive regulation of binding] GO:0055114 [oxidation-reduction process] GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity] GO:1902476 [chloride transmembrane transport]
