Expression of NAT2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

N-acetyltransferase 2 (arylamine N-acetyltransferase)

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043704

GENE INFORMATION
Gene name	NAT2 (HGNC Symbol)
Synonyms	AAC2
Description	N-acetyltransferase 2 (arylamine N-acetyltransferase) (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	18391245 - 18401218
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156006 (version 83.38)
Entrez gene	10
UniProt	P11245 (UniProt - Evidence at protein level)
neXtProt	NX_P11245
Antibodypedia	NAT2 antibodies

PROTEIN BROWSER

NAT2-001	NAT2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAT2-001 ENSP00000286479 ENST00000286479	P11245 [Direct mapping] Arylamine N-acetyltransferase 2 A4Z6T7 [Target identity:100%; Query identity:100%] Arylamine N-acetyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0004060 [arylamine N-acetyltransferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0016407 [acetyltransferase activity] GO:0044281 [small molecule metabolic process] Show all	290 aa 33.6 kDa	No	0
NAT2-002 ENSP00000428416 ENST00000520116	E7EWF9 [Direct mapping] Arylamine N-acetyltransferase 2 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016407 [acetyltransferase activity] Show all	160 aa 18.8 kDa	No	0