Fields »
ABOUT
HELP
BLOG
MMP16

GENERAL INFORMATION

Gene name

 MMP16

Gene description

 Matrix metallopeptidase 16 (membrane-inserted)

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA023693
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0246810TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0510152025Tags Per Million

GENE INFORMATION

Gene name

 MMP16 (HGNC Symbol)

Synonyms

 C8orf57, DKFZp761D112, MT3-MMP

Description

 Matrix metallopeptidase 16 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

Chromosome

 8

Cytoband

 q21.3

Chromosome location (bp)

 88032009 - 88328025

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156103 (version 83.38)

Entrez gene

 4325

UniProt

 P51512 (UniProt - Evidence at protein level)

neXtProt

 NX_P51512

Antibodypedia

 MMP16 antibodies

PROTEIN BROWSER
MMP16-001
MMP16-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP16-001
ENSP00000286614
ENST00000286614
P51512 [Direct mapping]
Matrix metalloproteinase-16
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001503 [ossification]
GO:0001958 [endochondral ossification]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0008047 [enzyme activator activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0035988 [chondrocyte proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0060348 [bone development]
GO:0097094 [craniofacial suture morphogenesis]
Show all
 607 aa
69.5 kDa 		Yes 1
MMP16-004
ENSP00000429147
ENST00000522726
E5RJA7 [Direct mapping]
Matrix metalloproteinase-16
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
 168 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.