Expression of DRAM2 in cancer - Summary

CANCER ATLAS

Gene description

DNA-damage regulated autophagy modulator 2

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018036	HPA061701

GENE INFORMATION
Gene name	DRAM2 (HGNC Symbol)
Synonyms	MGC54289, PRO180, RP5-1180E21.1, TMEM77, WWFQ154
Description	DNA-damage regulated autophagy modulator 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	111117333 - 111140216
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156171 (version 83.38)
Entrez gene	128338
UniProt	Q6UX65 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UX65
Antibodypedia	DRAM2 antibodies

PROTEIN BROWSER

DRAM2-001	DRAM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DRAM2-001 ENSP00000286692 ENST00000286692	Q6UX65 [Direct mapping] DNA damage-regulated autophagy modulator protein 2 A0A024R0B7 [Target identity:100%; Query identity:100%] Transmembrane protein 77, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	266 aa 29.8 kDa	No	6
DRAM2-201 ENSP00000437718 ENST00000539140	Q6UX65 [Direct mapping] DNA damage-regulated autophagy modulator protein 2 A0A024R0B7 [Target identity:100%; Query identity:100%] Transmembrane protein 77, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	266 aa 29.8 kDa	No	6