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CXCL13

GENERAL INFORMATION

Gene name

 CXCL13

Gene description

 Chemokine (C-X-C motif) ligand 13

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (lymph node, spleen, tonsil, appendix)
GTEx:Tissue enriched (spleen)
FANTOM5:Group enriched (spleen, lymph node, appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Extracellular deposits and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA052613
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lymph node, spleen, tonsil, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, lymph node, appendix, tonsil)

GENE INFORMATION

Gene name

 CXCL13 (HGNC Symbol)

Synonyms

 ANGIE, ANGIE2, BCA-1, BLC, BLR1L, SCYB13

Description

 Chemokine (C-X-C motif) ligand 13 (HGNC Symbol)

Entrez gene summary

 B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

Chromosome

 4

Cytoband

 q21.1

Chromosome location (bp)

 77511753 - 77611834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156234 (version 83.38)

Entrez gene

 10563

UniProt

 O43927 (UniProt - Evidence at protein level)

neXtProt

 NX_O43927

Antibodypedia

 CXCL13 antibodies

PROTEIN BROWSER
CXCL13-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCL13-001
ENSP00000286758
ENST00000286758
O43927 [Direct mapping]
C-X-C motif chemokine 13
Q53X90 [Target identity:100%; Query identity:100%]
C-X-C motif chemokine
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002467 [germinal center formation]
GO:0002518 [lymphocyte chemotaxis across high endothelial venule]
GO:0002544 [chronic inflammatory response]
GO:0002920 [regulation of humoral immune response]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0017134 [fibroblast growth factor binding]
GO:0031724 [CXCR5 chemokine receptor binding]
GO:0031735 [CCR10 chemokine receptor binding]
GO:0032496 [response to lipopolysaccharide]
GO:0033625 [positive regulation of integrin activation]
GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin]
GO:0035754 [B cell chemotaxis]
GO:0035768 [endothelial cell chemotaxis to fibroblast growth factor]
GO:0035769 [B cell chemotaxis across high endothelial venule]
GO:0042127 [regulation of cell proliferation]
GO:0042742 [defense response to bacterium]
GO:0045765 [regulation of angiogenesis]
GO:0046982 [protein heterodimerization activity]
GO:0048018 [receptor agonist activity]
GO:0048248 [CXCR3 chemokine receptor binding]
GO:0048535 [lymph node development]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0090630 [activation of GTPase activity]
GO:2000545 [negative regulation of endothelial cell chemotaxis to fibroblast growth factor]
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 109 aa
12.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.