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EEF1A1

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GENERAL INFORMATION

Gene name

 EEF1A1

Gene description

 Eukaryotic translation elongation factor 1 alpha 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA051759 , HPA053862
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051759 MCF7 Cytosol
HPA051759 PC-3 Cytosol
HPA051759 U-2 OS Cytosol
HPA053862 Hep G2 Cytosol
HPA053862 MCF7 No staining    
HPA053862 U-2 OS Cytosol

GENE INFORMATION

Gene name

 EEF1A1 (HGNC Symbol)

Synonyms

 EE1A1, EEF1A, EF1A, LENG7

Description

 Eukaryotic translation elongation factor 1 alpha 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q13

Chromosome location (bp)

 73515750 - 73523797

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156508 (version 83.38)

Entrez gene

 1915

UniProt

 P68104 (UniProt - Evidence at protein level)

neXtProt

 NX_P68104

Antibodypedia

 EEF1A1 antibodies

PROTEIN BROWSER
EEF1A1-001
EEF1A1-003
EEF1A1-004
EEF1A1-009
EEF1A1-015
EEF1A1-201
EEF1A1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EEF1A1-001
ENSP00000339063
ENST00000316292
P68104 [Direct mapping]
Elongation factor 1-alpha 1
Q6IPS9 [Target identity:100%; Query identity:100%]
Elongation factor 1-alpha
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030864 [cortical actin cytoskeleton]
GO:0032587 [ruffle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0071364 [cellular response to epidermal growth factor stimulus]
Show all
 462 aa
50.1 kDa 		No 0
EEF1A1-003
ENSP00000392366
ENST00000455918
A6PW80 [Direct mapping]
Elongation factor 1-alpha 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
Show all
 107 aa
12.1 kDa 		No 0
EEF1A1-004
ENSP00000330054
ENST00000331523
P68104 [Direct mapping]
Elongation factor 1-alpha 1
Q6IPS9 [Target identity:100%; Query identity:100%]
Elongation factor 1-alpha
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030864 [cortical actin cytoskeleton]
GO:0032587 [ruffle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0071364 [cellular response to epidermal growth factor stimulus]
Show all
 462 aa
50.1 kDa 		No 0
EEF1A1-009
ENSP00000339053
ENST00000309268
P68104 [Direct mapping]
Elongation factor 1-alpha 1
Q6IPS9 [Target identity:100%; Query identity:100%]
Elongation factor 1-alpha
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030864 [cortical actin cytoskeleton]
GO:0032587 [ruffle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0071364 [cellular response to epidermal growth factor stimulus]
Show all
 462 aa
50.1 kDa 		No 0
EEF1A1-015
ENSP00000348651
ENST00000356303
Q5JR01 [Direct mapping]
Elongation factor 1-alpha 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
Show all
 145 aa
15.9 kDa 		No 0
EEF1A1-201
ENSP00000479609
ENST00000610520
A0A087WVQ9 [Direct mapping]
Elongation factor 1-alpha 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
Show all
 441 aa
47.9 kDa 		No 0
EEF1A1-202
ENSP00000479055
ENST00000615060
A0A087WV01 [Direct mapping]
Elongation factor 1-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0006414 [translational elongation]
Show all
 426 aa
46.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.