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KAT6B

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GENERAL INFORMATION

Gene name

 KAT6B

Gene description

 K(lysine) acetyltransferase 6B

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Nuclear bodies (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA006104
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nuclear bodies.

Main location

 Nucleus (approved), Nuclear bodies (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006104 A-431 Nucleus
Nuclear bodies
HPA006104 U-2 OS Nucleus
HPA006104 U-251 MG Nucleus
Nuclear bodies

GENE INFORMATION

Gene name

 KAT6B (HGNC Symbol)

Synonyms

 Morf, MOZ2, MYST4, qkf, querkopf, ZC2HC6B

Description

 K(lysine) acetyltransferase 6B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 10

Cytoband

 q22.2

Chromosome location (bp)

 74825582 - 75032622

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156650 (version 83.38)

Entrez gene

 23522

UniProt

 Q8WYB5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYB5

Antibodypedia

 KAT6B antibodies

PROTEIN BROWSER
KAT6B-001
KAT6B-002
KAT6B-003
KAT6B-004
KAT6B-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KAT6B-001
ENSP00000361809
ENST00000372724
Q8WYB5 [Direct mapping]
Histone acetyltransferase KAT6B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 1781 aa
199.9 kDa 		No 0
KAT6B-002
ENSP00000361810
ENST00000372725
Q8WYB5 [Direct mapping]
Histone acetyltransferase KAT6B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 1781 aa
199.9 kDa 		No 0
KAT6B-003
ENSP00000287239
ENST00000287239
Q8WYB5 [Direct mapping]
Histone acetyltransferase KAT6B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0032403 [protein complex binding]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 2073 aa
231.4 kDa 		No 0
KAT6B-004
ENSP00000361796
ENST00000372711
Q8WYB5 [Direct mapping]
Histone acetyltransferase KAT6B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 1890 aa
211.5 kDa 		No 0
KAT6B-006
ENSP00000361799
ENST00000372714
Q8WYB5 [Direct mapping]
Histone acetyltransferase KAT6B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0043966 [histone H3 acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 1781 aa
199.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.