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Weak to moderate cytoplasmic staining was observed in a majority of malignancies. A few cases of malignant melanomas, colorectal, gastric and pancreatic cancers were strongly stained while several prostate cancers were negative.
GENE INFORMATION
Gene name
FRRS1 (HGNC Symbol)
Synonyms
SDFR2, SDR2
Description
Ferric-chelate reductase 1 (HGNC Symbol)
Entrez gene summary
Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]
