Tissue expression of EXOG - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EXOG
Gene description	Endo/exonuclease (5'-3'), endonuclease G-like
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	EXOG (HGNC Symbol)
Synonyms	ENDOGL1, ENDOGL2, ENGL, ENGL-a, ENGL-b
Description	Endo/exonuclease (5'-3'), endonuclease G-like (HGNC Symbol)
Entrez gene summary	This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38496127 - 38542161
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157036 (version 83.38)
Entrez gene	9941
UniProt	Q9Y2C4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2C4
Antibodypedia	EXOG antibodies

PROTEIN BROWSER

EXOG-001	EXOG-008	EXOG-016	EXOG-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOG-001 ENSP00000287675 ENST00000287675	Q9Y2C4 [Direct mapping] Nuclease EXOG, mitochondrial Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0003676 [nucleic acid binding] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0008150 [biological_process] GO:0016787 [hydrolase activity] GO:0043234 [protein complex] GO:0046872 [metal ion binding] Show all	368 aa 41.1 kDa	Yes	0
EXOG-008 ENSP00000404305 ENST00000422077	Q9Y2C4 [Direct mapping] Nuclease EXOG, mitochondrial Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0003676 [nucleic acid binding] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0005575 [cellular_component] GO:0005743 [mitochondrial inner membrane] GO:0008150 [biological_process] GO:0016787 [hydrolase activity] GO:0043234 [protein complex] GO:0046872 [metal ion binding] Show all	318 aa 35.4 kDa	Yes	0
EXOG-016 ENSP00000397124 ENST00000453767	H7C0W6 [Direct mapping] Nuclease EXOG, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0003676 [nucleic acid binding] GO:0004518 [nuclease activity] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	187 aa 21.1 kDa	No	0
EXOG-201 ENSP00000487559 ENST00000630638	F2Z2D3 [Direct mapping] Nuclease EXOG, mitochondrial Show all	SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000737 [DNA catabolic process, endonucleolytic] GO:0004518 [nuclease activity] Show all	56 aa 5.6 kDa	No	0