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ATP2B2

GENERAL INFORMATION

Gene name

 ATP2B2

Gene description

 ATPase, Ca++ transporting, plasma membrane 2

Protein class

 Enzymes
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:Tissue enhanced (cerebellum, brain, caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Highly expressed in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
CAB005606
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, brain, caudate)

GENE INFORMATION

Gene name

 ATP2B2 (HGNC Symbol)

Synonyms

 PMCA2

Description

 ATPase, Ca++ transporting, plasma membrane 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 10324023 - 10708031

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157087 (version 83.38)

Entrez gene

 491

UniProt

 Q01814 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01814

Antibodypedia

 ATP2B2 antibodies

PROTEIN BROWSER
ATP2B2-001
ATP2B2-002
ATP2B2-003
ATP2B2-005
ATP2B2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP2B2-001
ENSP00000324172
ENST00000352432
Q01814 [Direct mapping]
Plasma membrane calcium-transporting ATPase 2
A0A024R2K6 [Target identity:100%; Query identity:100%]
Calcium-transporting ATPase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0008022 [protein C-terminus binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1243 aa
136.9 kDa 		No >9
ATP2B2-002
ENSP00000373311
ENST00000383800
Q01814 [Direct mapping]
Plasma membrane calcium-transporting ATPase 2
A0A024R2E4 [Target identity:100%; Query identity:100%]
Calcium-transporting ATPase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0008022 [protein C-terminus binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1198 aa
132.6 kDa 		No >9
ATP2B2-003
ENSP00000414854
ENST00000452124
H0Y7S3 [Direct mapping]
Plasma membrane calcium-transporting ATPase 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1099 aa
121.3 kDa 		No 9
ATP2B2-005
ENSP00000380267
ENST00000397077
Q01814 [Direct mapping]
Plasma membrane calcium-transporting ATPase 2
A0A024R2E4 [Target identity:100%; Query identity:100%]
Calcium-transporting ATPase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0008022 [protein C-terminus binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1198 aa
132.6 kDa 		No >9
ATP2B2-201
ENSP00000353414
ENST00000360273
Q01814 [Direct mapping]
Plasma membrane calcium-transporting ATPase 2
A0A024R2K6 [Target identity:100%; Query identity:100%]
Calcium-transporting ATPase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006996 [organelle organization]
GO:0007595 [lactation]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0007626 [locomotory behavior]
GO:0008022 [protein C-terminus binding]
GO:0008361 [regulation of cell size]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0021549 [cerebellum development]
GO:0021692 [cerebellar Purkinje cell layer morphogenesis]
GO:0021702 [cerebellar Purkinje cell differentiation]
GO:0021707 [cerebellar granule cell differentiation]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0030899 [calcium-dependent ATPase activity]
GO:0034220 [ion transmembrane transport]
GO:0040011 [locomotion]
GO:0042428 [serotonin metabolic process]
GO:0042472 [inner ear morphogenesis]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0045299 [otolith mineralization]
GO:0046068 [cGMP metabolic process]
GO:0046872 [metal ion binding]
GO:0048167 [regulation of synaptic plasticity]
GO:0048839 [inner ear development]
GO:0050808 [synapse organization]
GO:0050885 [neuromuscular process controlling balance]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0060113 [inner ear receptor cell differentiation]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090102 [cochlea development]
Show all
 1243 aa
136.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.